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M9490365.TXT
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1994-09-19
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Document 0365
DOCN M9490365
TI Murine AIDS protects mice against experimental cerebral malaria:
down-regulation by interleukin 10 of a T-helper type 1 CD4+
cell-mediated pathology.
DT 9411
AU Eckwalanga M; Marussig M; Tavares MD; Bouanga JC; Hulier E; Pavlovitch
JH; Minoprio P; Portnoi D; Renia L; Mazier D; Institut National de la
Sante et de la Recherche Medicale,; Unite 313, Departement de
Parasitologie, Paris, France.
SO Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8097-101. Unique Identifier
: AIDSLINE MED/94336693
AB The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in
C57BL/6 mice that has many similarities with human AIDS; Plasmodium
berghei ANKA causes experimental cerebral malaria in the same strain of
mice. The outcome of malaria infection was studied in mice concurrently
infected with the two pathogens. The retrovirus significantly reduced
the gravity of the neurological manifestations associated with
Plasmodium berghei ANKA infection. The protection against experimental
cerebral malaria induced by murine AIDS increased with duration of viral
infection and, hence, with the severity of the immunodeficiency.
Interleukin 10, principally from splenic T cells, was shown to play a
crucial role in this protection.
DE Animal Antigens, CD4/*ANALYSIS Base Sequence Comparative Study
Defective Viruses/ISOLATION & PURIF DNA Primers Female Genome, Viral
Human Interleukin-10/*PHARMACOLOGY *Leukemia Viruses, Murine/ISOLATION
& PURIF *Lymphocyte Transformation Malaria,
Cerebral/IMMUNOLOGY/PATHOLOGY/*PREVENTION & CONTROL Mice Mice, Inbred
C57BL Molecular Sequence Data Murine Acquired Immunodeficiency
Syndrome/IMMUNOLOGY/PATHOLOGY/ *PHYSIOPATHOLOGY *Plasmodium berghei
Polymerase Chain Reaction Support, Non-U.S. Gov't T-Lymphocytes,
Helper-Inducer/DRUG EFFECTS/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).